|Other Names||Inhibin beta B chain, Activin beta-B chain, INHBB|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|
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The inhibin beta B subunit joins the alpha subunit toform a pituitary FSH secretion inhibitor. Inhibin has been shownto regulate gonadal stromal cell proliferation negatively and tohave tumour-suppressor activity. In addition, serum levels ofinhibin have been shown to reflect the size of granulosa-celltumors and can therefore be used as a marker for primary as well asrecurrent disease. Because expression in gonadal and variousextragonadal tissues may vary severalfold in a tissue-specificfashion, it is proposed that inhibin may be both agrowth/differentiation factor and a hormone. Furthermore, the betaB subunit forms a homodimer, activin B, and also joins with thebeta A subunit to form a heterodimer, activin AB, both of whichstimulate FSH secretion.
Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)Ewens, K.G., et al. J. Clin. Endocrinol. Metab. 95(5):2306-2315(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Ahn, J., et al. Hum. Mol. Genet. 18(19):3749-3757(2009)Makanji, Y., et al. Endocrinology 150(10):4784-4793(2009)
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