|Other Names||A-kinase anchor protein 17A, AKAP-17A, 721P, B-lymphocyte antigen, Protein XE7, Protein kinase A-anchoring protein 17A, PRKA17A, Splicing factor, arginine/serine-rich 17A, AKAP17A, CXYorf3, DXYS155E, SFRS17A, XE7|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CXYorf3, DXYS155E, SFRS17A, XE7|
|Function||Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre- mRNA splicing in a PKA-dependent manner.|
|Cellular Location||Nucleus speckle|
|Tissue Location||Widely expressed. Found in heart, brain, lung, liver, skeletal muscle, kidney and pancreas. Expressed in activated B-cells and placenta. Expressed in all cell lines tested including Jurkat-TAg, U-937 and HEK293 cells|
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Provided below are standard protocols that you may find useful for product applications.
This locus encodes a protein kinase A anchoring protein.The encoded protein is part of the spliceosome complex and isinvolved in the regulation of alternate splicing in some mRNAprecursors. Alternatively spliced transcript variants have beenidentified for this gene.
Jarnaess, E., et al. J. Biol. Chem. 284(50):35154-35164(2009)Mangs, A.H., et al. Nucleic Acids Res. 34(17):4976-4986(2006)Ried, K., et al. Hum. Mol. Genet. 7(11):1771-1778(1998)Ellison, J.W., et al. Hum. Mol. Genet. 1(9):691-696(1992)Voland, J.R., et al. Proc. Natl. Acad. Sci. U.S.A. 89(21):10425-10429(1992)
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