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IFT88 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q13099 |
|---|---|
| Clone Names | 91013156 |
| Gene ID | 8100 |
|---|---|
| Other Names | Intraflagellar transport protein 88 homolog, Recessive polycystic kidney disease protein Tg737 homolog, Tetratricopeptide repeat protein 10, TPR repeat protein 10, IFT88, TG737, TTC10 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | IFT88 |
|---|---|
| Synonyms | TG737, TTC10 |
| Function | Positively regulates primary cilium biogenesis (PubMed:17604723). Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment. |
| Cellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q61371}. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm {ECO:0000250|UniProtKB:Q61371}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q61371}. Note=Colocalizes with ENTR1 and gamma- tubulin at the basal body of primary cilia. Colocalizes with ENTR1 and pericentrin at the centrosome. |
| Tissue Location | Expressed in the heart, brain, liver, lung, kidney, skeletal muscle and pancreas. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the tetratrico peptiderepeat (TPR) family. Mutations of a similar gene in mouse can causepolycystic kidney disease. Two transcript variants encodingdistinct isoforms have been identified for this gene. [provided byRefSeq].
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Robert, A., et al. J. Cell. Sci. 120 (PT 4), 628-637 (2007) :Khanna, H., et al. J. Biol. Chem. 280(39):33580-33587(2005)Lehner, B., et al. Genomics 83(1):153-167(2004)Harrington, J.J., et al. Nat. Biotechnol. 19(5):440-445(2001)
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