|Other Names||Histone acetyltransferase KAT7, Histone acetyltransferase binding to ORC1, Lysine acetyltransferase 7, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2, MYST-2, KAT7, HBO1, HBOa, MYST2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1113a was selected from the N-term region of human HBO1/MYST2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||HBO1, HBOa, MYST2|
|Function||Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription.|
|Cellular Location||Nucleus, nucleoplasm|
|Tissue Location||Ubiquitously expressed, with highest levels in testis.|
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Provided below are standard protocols that you may find useful for product applications.
HBO1/MYST2 is a histone acetyltransferase which specifically represses AR-mediated transcription. It may play a role in DNA replication.
Wu,Z.Q., Proc. Natl. Acad. Sci. U.S.A. 105 (6), 1919-1924 (2008)Iizuka,M., Mol. Cell. Biol. 28 (1), 140-153 (2008)
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