|Other Names||Calcium/calmodulin-dependent protein kinase II inhibitor 2, CaM-KII inhibitory protein, CaM-KIIN, CAMK2N2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells. Traps Ca(2+)/calmodulin on CAMK2.|
|Cellular Location||Nucleus. Cytoplasm, cytosol. Note=Excluded from nucleus when coexpressed with activated CAMK2.|
|Tissue Location||Expressed in cell lines including hemopoietic cell lines and some tumor cell lines. Highly Expressed in stimulated dendritic cell (DC) and weakly expressed in unstimulated mature and immature DC. Highly expressed in kidney, liver, in cell lines HeLaS3, lymphoblastic leukemia MOLT-4, and Burkitt's lymphoma Raji. Moderately expressed in heart, skeletal muscle, placenta, and chronic myelogenous leukemia K-562 cells Weakly expressed in small intestine, colorectal adenocarcinoma SW480, and lung carcinoma A-549 cells|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that is highly similar to therat CaM-KII inhibitory protein, an inhibitor ofcalcium/calmodulin-dependent protein kinase II (CAMKII). CAMKIIregulates numerous physiological functions, including neuronalsynaptic plasticity through the phosphorylation ofalpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-typeglutamate (AMPA) receptors. Studies of the similar protein in ratsuggest that this protein may function as a negative regulator ofCaM-KII and may act to inhibit the phosphorylation of AMPAreceptors.
Ma, S., et al. J. Biol. Chem. 284(37):24773-24782(2009)Okabe, T., et al. J. Biol. Chem. 278(11):9920-9927(2003)Zhang, J., et al. Biochem. Biophys. Res. Commun. 285(2):229-234(2001)Chang, B.H., et al. Proc. Natl. Acad. Sci. U.S.A. 95(18):10890-10895(1998)
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