|Other Names||Tudor domain-containing protein 1, Cancer/testis antigen 411, CT411, TDRD1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins (By similarity).|
|Cellular Location||Cytoplasm. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis Also present in chromatoid body (By similarity).|
|Tissue Location||Testis and ovary specific. Also expressed in several cancers.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is similar to a mouse gene that encodes a tudordomain protein. Alternatively spliced transcript variants have beendescribed but their full length sequences have not been determined.
Wu, C., et al. Proteomics 7(11):1775-1785(2007)Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)Wang, P.J., et al. Nat. Genet. 27(4):422-426(2001)
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