|Other Names||Otoancorin, OTOA|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May act as an adhesion molecule.|
|Cellular Location||Apical cell membrane; Lipid- anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix. Note=At the interface between the apical surface of the epithelia and the overlying acellular gel of the tectorial and otoconial membranes.|
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The protein encoded by this gene is specifically expressedin the inner ear, and is located at the interface between theapical surface of the inner ear sensory epithelia and theiroverlying acellular gels. It is prposed that this protein isinvolved in the attachment of the inner ear acellular gels to theapical surface of the underlying nonsensory cells. Mutations inthis gene are associated with autosomal recessive deafness type 22(DFNB22). Alternatively spliced transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
Shahin, H., et al. Eur. J. Hum. Genet. 18(4):407-413(2010)Rose, J. Phd, et al. Mol. Med. (2010) In press :Hofmann, O., et al. Proc. Natl. Acad. Sci. U.S.A. 105(51):20422-20427(2008)Zwaenepoel, I., et al. Proc. Natl. Acad. Sci. U.S.A. 99(9):6240-6245(2002)
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