|Other Names||Integrator complex subunit 11, Int11, 3127-, Cleavage and polyadenylation-specific factor 3-like protein, CPSF3-like protein, Protein related to CPSF subunits of 68 kDa, RC-68, CPSF3L, INTS11, RC68|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalytic component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).|
|Cellular Location||Nucleus. Cytoplasm|
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Provided below are standard protocols that you may find useful for product applications.
The Integrator complex contains at least 12 subunits andassociates with the C-terminal domain of RNA polymerase II largesubunit (POLR2A; MIM 180660) and mediates the 3-prime endprocessing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2(RNU2; MIM 180690). INTS11, or CPSF3L, is the catalytic subunit ofthe Integrator complex (Baillat et al., 2005 [PubMed16239144]).
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Baillat, D., et al. Cell 123(2):265-276(2005)Dominski, Z., et al. Mol. Cell. Biol. 25(4):1489-1500(2005)
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