|Other Names||Protein THEMIS, Thymocyte-expressed molecule involved in selection, THEMIS, C6orf190, C6orf207|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk (By similarity).|
|Cellular Location||Cytoplasm. Nucleus|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that plays a regulatory rolein both positive and negative T-cell selection during latethymocyte development. The protein functions through T-cell antigenreceptor signaling, and is necessary for proper lineage commitmentand maturation of T-cells. Alternative splicing results in multipletranscript variants.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)Bhatti, P., et al. Radiat. Res. 173(2):214-224(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Patrick, M.S., et al. Proc. Natl. Acad. Sci. U.S.A. 106(38):16345-16350(2009)
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