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THEMIS Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8N1K5 |
|---|---|
| Clone Names | 100126082 |
| Gene ID | 387357 |
|---|---|
| Other Names | Protein THEMIS, Thymocyte-expressed molecule involved in selection, THEMIS, C6orf190, C6orf207 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | THEMIS |
|---|---|
| Synonyms | C6orf190, C6orf207 |
| Function | Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q8BGW0}. Nucleus {ECO:0000250|UniProtKB:Q8BGW0} |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein that plays a regulatory rolein both positive and negative T-cell selection during latethymocyte development. The protein functions through T-cell antigenreceptor signaling, and is necessary for proper lineage commitmentand maturation of T-cells. Alternative splicing results in multipletranscript variants.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)Bhatti, P., et al. Radiat. Res. 173(2):214-224(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Patrick, M.S., et al. Proc. Natl. Acad. Sci. U.S.A. 106(38):16345-16350(2009)
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