|Other Names||MTSS1-like protein, Actin-bundling with BAIAP2 homology protein 1, ABBA-1, MTSS1L|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in plasma membrane dynamics. Potentiated PDGF- mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation (PubMed:14752106). May function in actin bundling (PubMed:14752106).|
|Cellular Location||Cytoplasm. Cell projection, ruffle Note=Colocalizes with RAC1 within membrane ruffles|
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Provided below are standard protocols that you may find useful for product applications.
Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity).
Zheng, D., et al. Biochem. Biophys. Res. Commun. 401(4):527-532(2010)Yamagishi, A., et al. J. Biol. Chem. 279(15):14929-14936(2004)
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