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APG7L Antibody(D555) Blocking peptide

Synthetic peptide

Product Information
Primary Accession O95352
Clone Names 5011308
Peptide ID 5011308
Additional Information
Gene ID 10533
Other Names Ubiquitin-like modifier-activating enzyme ATG7, ATG12-activating enzyme E1 ATG7, Autophagy-related protein 7, APG7-like, hAGP7, Ubiquitin-activating enzyme E1-like protein, ATG7, APG7L
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ATG7
Synonyms APG7L
Function E1-like activating enzyme involved in the 2 ubiquitin- like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation.
Cellular Location Cytoplasm. Preautophagosomal structure. Note=Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme
Tissue Location Widely expressed, especially in kidney, liver, lymph nodes and bone marrow.
Research Areas
Citations (0)

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This gene was identified based on homology to Pichiapastoris GSA7 and Saccharomyces cerevisiae APG7. In the yeast, theprotein appears to be required for fusion of peroxisomal andvacuolar membranes. The protein shows homology to the ATP-bindingand catalytic sites of the E1 ubiquitin activating enzymes.


Metzger, S., et al. Hum. Genet. 128(4):453-459(2010)Zhao, Y., et al. Nat. Cell Biol. 12(7):665-675(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Xue, L.Y., et al. Autophagy 6(2):248-255(2010)Zhu, K., et al. Oncogene 29(3):451-462(2010)

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$ 80.00
Cat# BP11191a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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