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Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P23526 |
|---|---|
| Clone Names | 80102113 |
| Peptide ID | 80102113 |
| Gene ID | 191 |
|---|---|
| Other Names | Adenosylhomocysteinase, AdoHcyase, S-adenosyl-L-homocysteine hydrolase, AHCY, SAHH |
| Format | Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | AHCY |
|---|---|
| Synonyms | SAHH |
| Function | Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. |
| Cellular Location | Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV |
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Provided below are standard protocols that you may find useful for product applications.
Background
S-adenosylhomocysteine hydrolase belongs to theadenosylhomocysteinase family. It catalyzes the reversiblehydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado)and L-homocysteine (Hcy). Thus, it regulates the intracellularS-adenosylhomocysteine (SAH) concentration thought to be importantfor transmethylation reactions. Deficiency in this protein is oneof the different causes of hypermethioninemia. Alternativelyspliced transcript variants encoding different isoforms have beenfound for this gene.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Gass, N., et al. J Affect Disord 126 (1-2), 134-139 (2010) :Giusti, B., et al. Thromb. Haemost. 104(2):231-242(2010)Levine, A.J., et al. Cancer Epidemiol. Biomarkers Prev. 19(7):1812-1821(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
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