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AIF1 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P55008
Clone Names 80102116
Additional Information
Gene ID 199
Other Names Allograft inflammatory factor 1, AIF-1, Ionized calcium-binding adapter molecule 1, Protein G1, AIF1, G1, IBA1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name AIF1
Synonyms G1, IBA1
Function Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.
Cellular Location Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O70200}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:O70200}; Peripheral membrane protein {ECO:0000250|UniProtKB:O70200}; Cytoplasmic side {ECO:0000250|UniProtKB:O70200}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:O70200}. Note=Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis {ECO:0000250|UniProtKB:O70200}
Tissue Location Detected in T-lymphocytes and peripheral blood mononuclear cells.
Research Areas
Citations (0)
citation

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Background

This gene is induced by cytokines and interferon. Itsprotein product is thought to be involved in negative regulation ofgrowth of vascular smooth muscle cells, which contributes to theanti-inflammatory response to vessel wall trauma. Three transcriptvariants encoding different isoforms have been found for this gene.

References

Clancy, R.M., et al. Arthritis Rheum. 62(11):3415-3424(2010)Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Jia, J., et al. Pediatr. Res. 67(1):29-34(2010)Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009) :

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$ 277.78
Cat# BP11202b
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