|Other Names||Cytochrome P450 11B2, mitochondrial, Aldosterone synthase, ALDOS, Aldosterone-synthesizing enzyme, CYPXIB2, Cytochrome P-450Aldo, Cytochrome P-450C18, Steroid 18-hydroxylase, CYP11B2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Preferentially catalyzes the conversion of 11- deoxycorticosterone to aldosterone via corticosterone and 18- hydroxycorticosterone.|
|Cellular Location||Mitochondrion membrane.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the cytochrome P450superfamily of enzymes. The cytochrome P450 proteins aremonooxygenases which catalyze many reactions involved in drugmetabolism and synthesis of cholesterol, steroids and other lipids.This protein localizes to the mitochondrial inner membrane. Theenzyme has steroid 18-hydroxylase activity to synthesizealdosterone and 18-oxocortisol as well as steroid 11beta-hydroxylase activity. Mutations in this gene causecorticosterone methyl oxidase deficiency.
Wang, B., et al. Urology 76 (4), 1018 (2010) :Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Huriletemuer, H., et al. Neurosciences (Riyadh) 15(3):184-189(2010)Cheng, X., et al. Clin. Exp. Hypertens. 32(5):301-307(2010)Nelson, D.R., et al. Pharmacogenetics 14(1):1-18(2004)
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