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DNAL1 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q4LDG9 |
|---|---|
| Clone Names | 81028015 |
| Gene ID | 83544 |
|---|---|
| Other Names | Dynein light chain 1, axonemal, DNAL1, C14orf168 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DNAL1 (HGNC:23247) |
|---|---|
| Synonyms | C14orf168 |
| Function | Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity). Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-right asymmetry (PubMed:21496787). |
| Cellular Location | Cytoplasm, cytoskeleton, cilium axoneme |
| Tissue Location | Expressed in tissues carrying motile cilia such as respiratory epithelia, ependyma and testis |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
DNAL1 is a component of outer dynein arms, which containthe molecular motors for ATP-dependent cilia movement (Horvath etal., 2005 [PubMed 15845866]).
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :Horvath, J., et al. Am. J. Respir. Cell Mol. Biol. 33(1):41-47(2005)
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