EDN3 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P14138 |
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Clone Names | 80703062 |
Gene ID | 1908 |
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Other Names | Endothelin-3, ET-3, Preproendothelin-3, PPET3, EDN3 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | EDN3 |
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Function | Endothelins are endothelium-derived vasoconstrictor peptides. |
Cellular Location | Secreted. |
Tissue Location | Expressed in trophoblasts and placental stem villi vessels, but not in cultured placental smooth muscle cells |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of theendothelin family. Endothelins are endothelium-derived vasoactivepeptides involved in a variety of biological functions. The activeform of this protein is a 21 amino acid peptide processed from theprecursor protein. The active peptide is a ligand for endothelinreceptor type B (EDNRB). The interaction of this endothelin withEDNRB is essential for development of neural crest-derived celllineages, such as melanocytes and enteric neurons. Mutations inthis gene and EDNRB have been associated with Hirschsprung disease(HSCR) and Waardenburg syndrome (WS), which are congenitaldisorders involving neural crest-derived cells. Four alternativelyspliced transcript variants encoding three distinct isoforms havebeen observed.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Darrah, R., et al. Physiol. Genomics 41(1):71-77(2010)Sanchez-Mejias, A., et al. Genet. Med. 12(1):39-43(2010)Broasca, V., et al. Rom J Morphol Embryol 51(2):283-288(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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