|Other Names||Granzyme A, CTL tryptase, Cytotoxic T-lymphocyte proteinase 1, Fragmentin-1, Granzyme-1, Hanukkah factor, H factor, HF, GZMA, CTLA3, HFSP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.|
|Cellular Location||Isoform alpha: Secreted. Cytoplasmic granule|
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Provided below are standard protocols that you may find useful for product applications.
Cytolytic T lymphocytes (CTL) and natural killer (NK)cells share the remarkable ability to recognize, bind, and lysespecific target cells. They are thought to protect their host bylysing cells bearing on their surface 'nonself' antigens, usuallypeptides or proteins resulting from infection by intracellularpathogens. The protein described here is a T cell- and naturalkiller cell-specific serine protease that may function as a commoncomponent necessary for lysis of target cells by cytotoxic Tlymphocytes and natural killer cells.
Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)Pardo, J., et al. Blood 114 (18), 3968 (2009) :Zhu, P., et al. Blood 114(6):1205-1216(2009)Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009)Siezen, C.L., et al. Pediatr. Infect. Dis. J. 28(4):333-335(2009)
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