Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
INPP5E Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9NRR6 |
|---|---|
| Clone Names | 80513214 |
| Gene ID | 56623 |
|---|---|
| Other Names | 72 kDa inositol polyphosphate 5-phosphatase, Phosphatidylinositol 4, 5-bisphosphate 5-phosphatase, Phosphatidylinositol polyphosphate 5-phosphatase type IV, INPP5E |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | INPP5E |
|---|---|
| Function | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:10764818) (By similarity). Specific for lipid substrates, inactive towards water soluble inositol phosphates (PubMed:10764818). Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability (By similarity). |
| Cellular Location | Cytoplasm, cytoskeleton, cilium axoneme. Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q9JII1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JII1}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9JII1}. Cell membrane {ECO:0000250|UniProtKB:Q9WVR1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9WVR1}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9WVR1}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q9WVR1}. Cytoplasm {ECO:0000250|UniProtKB:Q9WVR1}. Nucleus {ECO:0000250|UniProtKB:Q9JII1} Note=Peripheral membrane protein associated with Golgi stacks {ECO:0000250|UniProtKB:Q9JII1} |
| Tissue Location | Detected in brain, heart, pancreas, testis and spleen. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is an inositol1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphataseshydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium andacts as a second messenger mediating cell responses to variousstimulation. Studies of the mouse counterpart suggest that thisprotein may hydrolyze phosphatidylinositol 3,4, 5-trisphosphate andphosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgimembrane and thereby regulate Golgi-vesicular trafficking.
References
Bielas, S.L., et al. Nat. Genet. 41(9):1032-1036(2009)Jacoby, M., et al. Nat. Genet. 41(9):1027-1031(2009)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Jin, J., et al. Curr. Biol. 14(16):1436-1450(2004)Kong, A.M., et al. J. Biol. Chem. 275(31):24052-24064(2000)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
