|Other Names||GTP-binding protein GEM, GTP-binding mitogen-induced T-cell protein, RAS-like protein KIR, GEM, KIR|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.|
|Cellular Location||Cell membrane; Peripheral membrane protein; Cytoplasmic side|
|Tissue Location||Most abundant in thymus, spleen, kidney, lung, and testis. Less abundant in heart, brain, liver and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the RAD/GEMfamily of GTP-binding proteins. It is associated with the innerface of the plasma membrane and could play a role as a regulatoryprotein in receptor-mediated signal transduction. Alternativesplicing occurs at this locus and two transcript variants encodingthe same protein have been identified.
Wang, A., et al. J. Bacteriol. 192(11):2809-2815(2010)Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)Splingard, A., et al. J. Biol. Chem. 282(3):1905-1915(2007)Opatowsky, Y., et al. FEBS Lett. 580(25):5959-5964(2006)Kelly, K. Trends Cell Biol. 15(12):640-643(2005)
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