|Other Names||Histone H2AZ, H2A/z, H2AFZ, H2AZ|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.|
|Cellular Location||Nucleus. Chromosome.|
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Histones are basic nuclear proteins that are responsiblefor the nucleosome structure of the chromosomal fiber ineukaryotes. Nucleosomes consist of approximately 146 bp of DNAwrapped around a histone octamer composed of pairs of each of thefour core histones (H2A, H2B, H3, and H4). The chromatin fiber isfurther compacted through the interaction of a linker histone, H1,with the DNA between the nucleosomes to form higher order chromatinstructures. This gene encodes a replication-independent member ofthe histone H2A family that is distinct from other members of thefamily. Studies in mice have shown that this particular histone isrequired for embryonic development and indicate that lack offunctional histone H2A leads to embryonic lethality. [provided byRefSeq].
Marques, M., et al. Epigenetics 5(4):267-272(2010)Svotelis, A., et al. Cell Cycle 9(2):364-370(2010)Thakar, A., et al. Biochemistry 48(46):10852-10857(2009)Hardy, S., et al. PLoS Genet. 5 (10), E1000687 (2009) :Gevry, N., et al. Genes Dev. 23(13):1522-1533(2009)
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