|Other Names||Endoglin, CD105, ENG, END|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF- beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGF-beta1 signaling through SMAD3.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Endoglin is restricted to endothelial cells in all tissues except bone marrow|
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This gene encodes a homodimeric transmembrane proteinwhich is a major glycoprotein of the vascular endothelium. Thisprotein is a component of the transforming growth factor betareceptor complex and it binds TGFB1 and TGFB3 with high affinity.Mutations in this gene cause hereditary hemorrhagic telangiectasia,also known as Osler-Rendu-Weber syndrome 1, an autosomal dominantmultisystemic vascular dysplasia. Alternatively spliced transcriptvariants encoding different isoforms have been found for this gene.
Lopez-Novoa, J.M., et al. Am. J. Physiol. Heart Circ. Physiol. 299 (4), H959-H974 (2010) :Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Zabaneh, D., et al. PLoS ONE 5 (8), E11961 (2010) :Maynard, S.E., et al. Hypertens Pregnancy 29(3):330-341(2010)Rius, C., et al. Blood 92(12):4677-4690(1998)
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