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CRH Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P06850 |
|---|---|
| Clone Names | 90429086 |
| Gene ID | 1392 |
|---|---|
| Other Names | Corticoliberin, Corticotropin-releasing factor, CRF, Corticotropin-releasing hormone, CRH |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CRH |
|---|---|
| Function | Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity). |
| Cellular Location | Secreted {ECO:0000250|UniProtKB:P06296}. |
| Tissue Location | Produced by the hypothalamus and placenta. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Corticotropin-releasing hormone is secreted by theparaventricular nucleus (PVN) of the hypothalamus in response tostress. Marked reduction in this protein has been observed inassociation with Alzheimer disease and autosomal recessivehypothalamic corticotropin deficiency has multiple and potentiallyfatal metabolic consequences including hypoglycemia and hepatitis.In addition to production in the hypothalamus, this protein is alsosynthesized in peripheral tissues, such as T lymphocytes and ishighly expressed in the placenta. In the placenta it is a markerthat determines the length of gestation and the timing ofparturition and delivery. A rapid increase in circulating levels ofthe hormone occurs at the onset of parturition, suggesting that, inaddition to its metabolic functions, this protein may act as atrigger for parturition.
References
Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :Holliday, K.L., et al. J Psychosom Res 68(5):469-474(2010)Binder, E.B., et al. Arch. Gen. Psychiatry 67(4):369-379(2010)Kageyama, K., et al. Vitam. Horm. 82, 301-317 (2010) :
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