|Other Names||Corticoliberin, Corticotropin-releasing factor, CRF, Corticotropin-releasing hormone, CRH|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||This hormone from hypothalamus regulates the release of corticotropin from pituitary gland.|
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Corticotropin-releasing hormone is secreted by theparaventricular nucleus (PVN) of the hypothalamus in response tostress. Marked reduction in this protein has been observed inassociation with Alzheimer disease and autosomal recessivehypothalamic corticotropin deficiency has multiple and potentiallyfatal metabolic consequences including hypoglycemia and hepatitis.In addition to production in the hypothalamus, this protein is alsosynthesized in peripheral tissues, such as T lymphocytes and ishighly expressed in the placenta. In the placenta it is a markerthat determines the length of gestation and the timing ofparturition and delivery. A rapid increase in circulating levels ofthe hormone occurs at the onset of parturition, suggesting that, inaddition to its metabolic functions, this protein may act as atrigger for parturition.
Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :Holliday, K.L., et al. J Psychosom Res 68(5):469-474(2010)Binder, E.B., et al. Arch. Gen. Psychiatry 67(4):369-379(2010)Kageyama, K., et al. Vitam. Horm. 82, 301-317 (2010) :
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