|Other Names||Testis-specific serine/threonine-protein kinase 4, TSK-4, TSSK-4, Testis-specific kinase 4, Serine/threonine-protein kinase 22E, TSSK4, C14orf20, STK22E, TSSK5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||C14orf20, STK22E, TSSK5|
|Function||May be involved in a signaling pathway during male germ cell development or mature sperm function (By similarity). Phosphorylates CREB1 on Ser-133 and stimulates downstream signaling.|
|Tissue Location||Expressed only in the testis.|
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This gene encodes a member of the testis-specificserine/threonine kinase family. The encoded protein is thought tobe involved in spermatogenesis via stimulation of the CREB/CREresponsive pathway through phosphorylation of the cAMP responsiveelement binding protein transcription factor. Alternative splicingresults in multiple transcript variants.
Aston, K.I., et al. Hum. Reprod. 25(6):1383-1397(2010)Su, D., et al. J. Androl. 29(4):374-378(2008)Zeng, M., et al. BMB Rep 41(4):300-304(2008)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Chen, X., et al. Biochem. Biophys. Res. Commun. 333(3):742-749(2005)
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