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JAK1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P23458
Clone Names 2121605
Additional Information
Gene ID 3716
Other Names Tyrosine-protein kinase JAK1, Janus kinase 1, JAK-1, JAK1, JAK1A, JAK1B
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1124b was selected from the C-term region of human JAK1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name JAK1
Synonyms JAK1A, JAK1B
Function Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.
Cellular Location Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated
Tissue Location Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.
Research Areas
Citations (0)

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Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.


Yokota, S., et al., Virology 306(1):135-146 (2003).Usacheva, A., et al., J. Biol. Chem. 277(50):48220-48226 (2002).Radtke, S., et al., J. Biol. Chem. 277(13):11297-11305 (2002).Muller, M., et al., Nature 366(6451):129-135 (1993).Howard, O.M., et al., Oncogene 7(5):895-900 (1992).

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$ 80.00
Cat# BP1124b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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