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KRT25 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q7Z3Z0 |
|---|---|
| Clone Names | 100120185 |
| Gene ID | 147183 |
|---|---|
| Other Names | Keratin, type I cytoskeletal 25, Cytokeratin-25, CK-25, Keratin-25, K25, Keratin-25A, K25A, Type I inner root sheath-specific keratin-K25irs1, KRT25 (HGNC:30839) |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | KRT25 (HGNC:30839) |
|---|---|
| Function | Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization (PubMed:26902920). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q8VCW2}. |
| Tissue Location | Strongly expressed in skin and scalp, and weak expression observed in thymus and tongue. In the hair follicle, expressed in Henle layer, Huxley layer and in the inner root sheath cuticle of the hair follicle. Expression extends from the bulb region up to the point of differentiation into the three layers. Also present in the medulla of beard hair (at protein level) |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the type I (acidic) keratinfamily, which belongs to the superfamily of intermediate filament(IF) proteins. Keratins are heteropolymeric structural proteinswhich form the intermediate filament. These filaments, along withactin microfilaments and microtubules, compose the cytoskeleton ofepithelial cells. The type I keratin genes are clustered in aregion of chromosome 17q12-q21.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :Schweizer, J., et al. J. Cell Biol. 174(2):169-174(2006)Rogers, M.A., et al. Differentiation 72 (9-10), 527-540 (2004) :Hesse, M., et al. Eur. J. Cell Biol. 83(1):19-26(2004)
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