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C4orf21 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q86YA3
Other Accession NP_060862.2
Clone Names 100111237
Additional Information
Gene ID 55345
Other Names Protein ZGRF1, GRF-type zinc finger domain-containing protein 1, ZGRF1, C4orf21
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZGRF1
Synonyms C4orf21
Function 5'-3' DNA helicase which is recruited to sites of DNA damage and promotes repair of replication-blocking DNA lesions through stimulation of homologous recombination (HR) (PubMed:32640219, PubMed:34552057). Promotes HR by directly stimulating RAD51-mediated strand exchange activity (PubMed:32640219). Not required to load RAD51 at sites of DNA damage but promotes recombinational repair after RAD51 recruitment (PubMed:32640219). Also promotes HR by positively regulating EXO1-mediated DNA end resection of double-strand breaks (PubMed:34552057). Required for recruitment of replication protein RPA2 to DNA damage sites (PubMed:34552057). Promotes the initiation of the G2/M checkpoint but not its maintenance (PubMed:34552057). Catalyzes Holliday junction branch migration and dissociation of D-loops and DNA flaps (PubMed:32640219).
Cellular Location Nucleus.
Research Areas
Citations (0)
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$ 277.78
Cat# BP11267a
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