|Other Names||DNA-directed RNA polymerase II subunit RPB11-a, RNA polymerase II subunit B11-a, RPB11a, DNA-directed RNA polymerase II subunit J-1, RNA polymerase II 133 kDa subunit, POLR2J, POLR2J1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).|
|Tissue Location||Ubiquitously expressed. High expression was found in heart and skeletal muscle.|
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This gene encodes a subunit of RNA polymerase II, thepolymerase responsible for synthesizing messenger RNA ineukaryotes. The product of this gene exists as a heterodimer withanother polymerase subunit; together they form a core subassemblyunit of the polymerase. Two similar genes are located nearby onchromosome 7q22.1 and a pseudogene is found on chromosome 7p13.
Michiels, S., et al. Carcinogenesis 30(5):763-768(2009)Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)Shpakovskii, D.G., et al. Bioorg. Khim. 30(6):621-625(2004)Zhou, M., et al. Proc. Natl. Acad. Sci. U.S.A. 100(22):12666-12671(2003)Kaehlcke, K., et al. Mol. Cell 12(1):167-176(2003)
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