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POLR2J Antibody (C-Term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P52435 |
|---|---|
| Clone Names | 91023015 |
| Gene ID | 5439 |
|---|---|
| Other Names | DNA-directed RNA polymerase II subunit RPB11-a, RNA polymerase II subunit B11-a, RPB11a, DNA-directed RNA polymerase II subunit J-1, RNA polymerase II 133 kDa subunit, POLR2J, POLR2J1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | POLR2J |
|---|---|
| Synonyms | POLR2J1 |
| Function | Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates. |
| Cellular Location | Nucleus. |
| Tissue Location | Ubiquitously expressed. High expression was found in heart and skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a subunit of RNA polymerase II, thepolymerase responsible for synthesizing messenger RNA ineukaryotes. The product of this gene exists as a heterodimer withanother polymerase subunit; together they form a core subassemblyunit of the polymerase. Two similar genes are located nearby onchromosome 7q22.1 and a pseudogene is found on chromosome 7p13.
References
Michiels, S., et al. Carcinogenesis 30(5):763-768(2009)Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)Shpakovskii, D.G., et al. Bioorg. Khim. 30(6):621-625(2004)Zhou, M., et al. Proc. Natl. Acad. Sci. U.S.A. 100(22):12666-12671(2003)Kaehlcke, K., et al. Mol. Cell 12(1):167-176(2003)
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