|Other Names||HAUS augmin-like complex subunit 3, HAUS3, C4orf15|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Note=Localizes to interphase centrosomes and to mitotic spindle microtubules.|
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HAUS3 is 1 of 8 subunits of the 390-kD human augmincomplex, or HAUS complex. The augmin complex was first identifiedin Drosophila, and its name comes from the Latin verb 'augmentare,'meaning 'to increase.' The augmin complex is a microtubule-bindingcomplex involved in microtubule generation within the mitoticspindle and is vital to mitotic spindle assembly (Goshima et al.,2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed19369198]).
Shah, S.P., et al. Nature 461(7265):809-813(2009)Lawo, S., et al. Curr. Biol. 19(10):816-826(2009)Uehara, R., et al. Proc. Natl. Acad. Sci. U.S.A. 106(17):6998-7003(2009)Goshima, G., et al. J. Cell Biol. 181(3):421-429(2008)
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