|Other Names||Cyclin-dependent kinase 16, Cell division protein kinase 16, PCTAIRE-motif protein kinase 1, Serine/threonine-protein kinase PCTAIRE-1, CDK16, PCTAIRE1, PCTK1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser- 336' (in vitro).|
|Cellular Location||Cytoplasm. Cytoplasmic vesicle, secretory vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, synaptosome Note=Colocalizes with insulin in pancreas islets. Recruited to the cell membrane by CCNY|
|Tissue Location||Detected in pancreas islets (at protein level). Detected in brain and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the cdc2/cdkxsubfamily of the ser/thr family of protein kinases. It may play arole in signal transduction cascades in terminally differentiatedcells; in exocytosis; and in transport of secretory cargo from theendoplasmic reticulum. This gene is thought to escape Xinactivation. Alternative splicing results in multiple transcriptvariants encoding different isoforms.
Malumbres, M., et al. Nat. Cell Biol. 11(11):1275-1276(2009)Liu, Y., et al. J. Biol. Chem. 281(15):9852-9858(2006)Palmer, K.J., et al. J. Cell. Sci. 118 (PT 17), 3839-3847 (2005) :Graeser, R., et al. J. Cell. Sci. 115 (PT 17), 3479-3490 (2002) :Esposito, T., et al. Genomics 43(2):183-190(1997)
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