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PCTK1 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q00536 |
|---|---|
| Clone Names | 6030452 |
| Gene ID | 5127 |
|---|---|
| Other Names | Cyclin-dependent kinase 16, Cell division protein kinase 16, PCTAIRE-motif protein kinase 1, Serine/threonine-protein kinase PCTAIRE-1, CDK16, PCTAIRE1, PCTK1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CDK16 |
|---|---|
| Synonyms | PCTAIRE1, PCTK1 |
| Function | Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). |
| Cellular Location | Cytoplasm. Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:Q63686} Cell membrane; Peripheral membrane protein; Cytoplasmic side. Synapse, synaptosome {ECO:0000250|UniProtKB:Q63686}. Note=Colocalizes with insulin in pancreas islets. Recruited to the cell membrane by CCNY |
| Tissue Location | Detected in pancreas islets (at protein level). Detected in brain and pancreas. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the cdc2/cdkxsubfamily of the ser/thr family of protein kinases. It may play arole in signal transduction cascades in terminally differentiatedcells; in exocytosis; and in transport of secretory cargo from theendoplasmic reticulum. This gene is thought to escape Xinactivation. Alternative splicing results in multiple transcriptvariants encoding different isoforms.
References
Malumbres, M., et al. Nat. Cell Biol. 11(11):1275-1276(2009)Liu, Y., et al. J. Biol. Chem. 281(15):9852-9858(2006)Palmer, K.J., et al. J. Cell. Sci. 118 (PT 17), 3839-3847 (2005) :Graeser, R., et al. J. Cell. Sci. 115 (PT 17), 3479-3490 (2002) :Esposito, T., et al. Genomics 43(2):183-190(1997)
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