|Other Names||Adenylate cyclase type 2, ATP pyrophosphate-lyase 2, Adenylate cyclase type II, Adenylyl cyclase 2, ADCY2, KIAA1060|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity).|
|Cellular Location||Membrane; Multi-pass membrane protein. Cell membrane; Multi- pass membrane protein. Cytoplasm|
|Tissue Location||Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Expressed in brain, especially in caudate nucleus, cerebellum and hippocampus.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the family of adenylatecyclases, which are membrane-associated enzymes that catalyze theformation of the secondary messenger cyclic adenosine monophosphate(cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and isstimulated by the G protein beta and gamma subunit complex.
Halls, M.L., et al. EMBO J. 29(16):2772-2787(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Need, A.C., et al. Eur. J. Hum. Genet. 17(7):946-957(2009)Uhl, G.R., et al. Arch. Gen. Psychiatry 65(6):683-693(2008)Sunahara, R.K., et al. Mol. Interv. 2(3):168-184(2002)
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