|Other Names||Cyclin-G1, Cyclin-G, CCNG1, CCNG, CYCG1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity).|
|Cellular Location||Nucleus. Note=DNA replication foci after DNA damage|
|Tissue Location||High levels in skeletal muscle, ovary, kidney and colon|
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Provided below are standard protocols that you may find useful for product applications.
The eukaryotic cell cycle is governed by cyclin-dependentprotein kinases (CDKs) whose activities are regulated by cyclinsand CDK inhibitors. The protein encoded by this gene is a member ofthe cyclin family and contains the cyclin box. The encoded proteinlacks the protein destabilizing (PEST) sequence that is present inother family members. Transcriptional activation of this gene canbe induced by tumor protein p53. Two transcript variants encodingthe same protein have been identified for this gene. [provided byRefSeq].
Cunningham, J.M., et al. Br. J. Cancer 101(8):1461-1468(2009)Fornari, F., et al. Cancer Res. 69(14):5761-5767(2009)Li, H., et al. Mol. Cell. Biol. 29(3):919-928(2009)Piscopo, D.M., et al. Cancer Res. 68(14):5581-5590(2008)Seo, H.R., et al. J. Biol. Chem. 283(23):15601-15610(2008)
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