PSMB11 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | A5LHX3 |
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Clone Names | 100120184 |
Gene ID | 122706 |
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Other Names | Proteasome subunit beta type-11, Proteasome subunit beta-5t, PSMB11 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PSMB11 |
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Function | The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome (By similarity). Plays a pivotal role in development of CD8-positive T cells (By similarity). |
Cellular Location | Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00809}. Nucleus |
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Provided below are standard protocols that you may find useful for product applications.
Background
Proteasomes generate peptides that are presented by majorhistocompatibility complex (MHC) I molecules to other cells of theimmune system. Proteolysis is conducted by 20S proteasomes,complexes of 28 subunits arranged as a cylinder in 4heteroheptameric rings: alpha-1 to -7, beta-1 to -7, beta-1 to -7,and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6; MIM600307), beta-2 (PSMB7; MIM 604030), and beta-5 (PSMB5; MIM600306). Three additional subunits, beta-1i (PSMB9; MIM 177045),beta-2i (PSMB10; MIM 176847), and beta-5i (PSMB8; MIM 177046), areinduced by gamma-interferon (IFNG; MIM 147570) and arepreferentially incorporated into proteasomes to makeimmunoproteasomes. PSMB11, or beta-5t, is a catalytic subunitexpressed exclusively in cortical thymic epithelial cells (Murataet al., 2007 [PubMed 17540904]).
References
Tomaru, U., et al. Blood 113(21):5186-5191(2009)Murata, S., et al. Science 316(5829):1349-1353(2007)
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