CCDC115 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q96NT0 |
---|---|
Other Accession | NP_115733.2 |
Clone Names | 100120271 |
Gene ID | 84317 |
---|---|
Other Names | Coiled-coil domain-containing protein 115, CCDC115 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CCDC115 {ECO:0000303|PubMed:26833332, ECO:0000312|HGNC:HGNC:28178} |
---|---|
Function | Accessory component of the proton-transporting vacuolar (V)- ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (PubMed:28296633). May be involved in Golgi homeostasis (PubMed:26833332). |
Cellular Location | Endosome {ECO:0000250|UniProtKB:Q8VE99}. Lysosome {ECO:0000250|UniProtKB:Q8VE99}. Endoplasmic reticulum-Golgi intermediate compartment. Cytoplasmic vesicle, COPI-coated vesicle. Endoplasmic reticulum |
Tissue Location | Expressed throughout the brain. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.