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UBXN2A Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P68543
Other Accession NP_859064.2
Clone Names 100126081
Additional Information
Gene ID 165324
Other Names UBX domain-containing protein 2A, UBX domain-containing protein 4, UBXN2A, UBXD4
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name UBXN2A (HGNC:27265)
Function Acts to repress the ubiquitination and subsequent endoplasmic reticulum-associated degradation of CHRNA3 by the STUB1-VCP-UBXN2A complex in cortical neurons (PubMed:26265139). Also acts to promote the translocation of CHRNA3 to the plasma membrane and subsequently increases plasma membrane acetylcholine-gated ion-channel activation (By similarity). Plays a role in the inhibition of STUB1-mediated TP53 degradation, via its interaction with HSPA9 which acts to inhibit TP53 binding to HSPA9 (PubMed:24625977, PubMed:26634371). Positively mediates the ubiquitination and proteosomal degradation of RICTOR, may thereby act as a negative regulator of the mTORC2 pathway (PubMed:37037900).
Cellular Location Golgi apparatus {ECO:0000250|UniProtKB:Q99KJ0}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q99KJ0}. Perikaryon {ECO:0000250|UniProtKB:Q99KJ0}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q99KJ0}. Nucleus Cytoplasm. Note=Expressed at the axon initial segment. {ECO:0000250|UniProtKB:Q99KJ0}
Tissue Location Expressed in the colon (at protein level).
Research Areas
Citations (0)
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References

Lowe, J.K., et al. PLoS Genet. 5 (2), E1000365 (2009) :

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$ 277.78
Cat# BP11361b
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