UBXN2A Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P68543 |
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Other Accession | NP_859064.2 |
Clone Names | 100126081 |
Gene ID | 165324 |
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Other Names | UBX domain-containing protein 2A, UBX domain-containing protein 4, UBXN2A, UBXD4 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | UBXN2A (HGNC:27265) |
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Function | Acts to repress the ubiquitination and subsequent endoplasmic reticulum-associated degradation of CHRNA3 by the STUB1-VCP-UBXN2A complex in cortical neurons (PubMed:26265139). Also acts to promote the translocation of CHRNA3 to the plasma membrane and subsequently increases plasma membrane acetylcholine-gated ion-channel activation (By similarity). Plays a role in the inhibition of STUB1-mediated TP53 degradation, via its interaction with HSPA9 which acts to inhibit TP53 binding to HSPA9 (PubMed:24625977, PubMed:26634371). Positively mediates the ubiquitination and proteosomal degradation of RICTOR, may thereby act as a negative regulator of the mTORC2 pathway (PubMed:37037900). |
Cellular Location | Golgi apparatus {ECO:0000250|UniProtKB:Q99KJ0}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q99KJ0}. Perikaryon {ECO:0000250|UniProtKB:Q99KJ0}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q99KJ0}. Nucleus Cytoplasm. Note=Expressed at the axon initial segment. {ECO:0000250|UniProtKB:Q99KJ0} |
Tissue Location | Expressed in the colon (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
References
Lowe, J.K., et al. PLoS Genet. 5 (2), E1000365 (2009) :
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