|Other Names||Transmembrane protein 201, Spindle-associated membrane protein 1, TMEM201, NET5, SAMP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in nuclear movement during fibroblast polarization and migration. Proposed to be involved in actin- dependent nuclear movement via association with transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery (PubMed:27541860).|
|Cellular Location||Isoform 2: Nucleus inner membrane; Multi- pass membrane protein. Cytoplasm, cytoskeleton, spindle pole. Note=The C-terminal of isoform 2 is located on the nucleoplasmic side During interphase, isoform 2 is distributed in the inner nuclear membrane in distinct micro-domains and during mitosis, it is found in the ER but it also localizes to the polar regions of the mitotic spindle.|
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Provided below are standard protocols that you may find useful for product applications.
Isoform SAMP1 may define a distinct membrane domain in the vicinity of the mitotic spindle.
Buch, C., et al. J. Cell. Sci. 122 (PT 12), 2100-2107 (2009) :
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