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EDN1 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P05305 |
|---|---|
| Clone Names | 81201045 |
| Gene ID | 1906 |
|---|---|
| Other Names | Endothelin-1, Preproendothelin-1, PPET1, Endothelin-1, ET-1, Big endothelin-1, EDN1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | EDN1 |
|---|---|
| Function | Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (PubMed:19086031). Also binds the DEAR/FBXW7-AS1 receptor (PubMed:17446437). Promotes mesenteric arterial wall remodeling via activation of ROCK signaling and subsequent colocalization of NFATC3 with F-actin filaments (By similarity). NFATC3 then translocates to the nucleus where it subsequently promotes the transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity). |
| Cellular Location | Secreted. |
| Tissue Location | Expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is proteolyticallyprocessed to release a secreted peptide termed endothelin 1. Thispeptide is a potent vasoconstrictor and is produced by vascularendothelial cells. Endothelin 1 also can affect the central nervoussystem. Two transcript variants encoding different isoforms havebeen found for this gene.
References
Gonsalves, C., et al. J. Immunol. 185(10):6253-6264(2010)Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Feng, J., et al. Circulation 122 (11 SUPPL), S150-S155 (2010) :Nikopensius, T., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(9):748-756(2010)Kaparianos, A., et al. Eur Rev Med Pharmacol Sci 14(8):705-719(2010)
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