|Other Names||Glutamate receptor ionotropic, NMDA 2A, GluN2A, Glutamate [NMDA] receptor subunit epsilon-1, N-methyl D-aspartate receptor subtype 2A, NMDAR2A, NR2A, hNR2A, GRIN2A, NMDAR2A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein|
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N-methyl-D-aspartate (NMDA) receptors are a class ofionotropic glutamate-gated ion channels. These receptors have beenshown to be involved in long-term potentiation, anactivity-dependent increase in the efficiency of synaptictransmission thought to underlie certain kinds of memory andlearning. NMDA receptor channels are heteromers composed of the keyreceptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) andNMDAR2D (GRIN2D). Alternatively spliced transcript variantsencoding different isoforms have been found for this gene.
Endele, S., et al. Nat. Genet. 42(11):1021-1026(2010)Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :King, J.E., et al. Am. J. Pathol. 176(6):2819-2830(2010)
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