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F8A2 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P23610 |
|---|---|
| Clone Names | 100203150 |
| Gene ID | 474383;474384;8263 |
|---|---|
| Other Names | Factor VIII intron 22 protein, CpG island protein, F8A1, F8A |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | F8A1 |
|---|---|
| Function | RAB5A effector molecule that is involved in vesicular trafficking of early endosomes (PubMed:16476778). Mediates the recruitment of HTT by RAB5A onto early endosomes. The HTT- F8A1/F8A2/F8A3-RAB5A complex stimulates early endosomal interaction with actin filaments and inhibits interaction with microtubules, leading to the reduction of endosome motility (PubMed:16476778). |
| Cellular Location | Cytoplasm. Nucleus. Early endosome. Nucleus, nuclear body {ECO:0000250|UniProtKB:Q00558}. Note=Diffuse presence in the cytoplasm and accumulation in the nucleus (PubMed:16476778). In absence of HTT, F8A1/F8A2/F8A3 is concentred in cytoplasm (By similarity). Colocalized with HTT in endosomes (PubMed:16476778). In neuron found in intranuclear structures, the intranuclear rodlets (INRs), also known as rodlets of Roncoroni, in association with ubiquitin (By similarity) {ECO:0000250|UniProtKB:Q00558, ECO:0000269|PubMed:16476778} |
| Tissue Location | Produced abundantly in a wide variety of cell types |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is part of a region that is repeated three timeson chromosome X, once in intron 22 of the F8 gene and twice closerto the Xq telomere. This record represents the middle copy.Although its function is unknown, the observation that this gene isconserved in the mouse implies it has some function. Unlike factorVIII, this gene is transcribed abundantly in a wide variety of celltypes.
References
Bagnall, R.D., et al. Genome Res. 15(2):214-223(2005)Naylor, J.A., et al. Hum. Mol. Genet. 4(7):1217-1224(1995)
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