|Target/Specificity||The synthetic peptide sequence used to generate the antibody AM1141b was selected from the region of human CEM15. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
CEM15 is a member of the cytidine deaminase family. It is produced from one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. The protein encoded by this gene has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity.
Kao, S., et al., J. Virol. 77(21):11398-11407 (2003).Stopak, K., et al., Mol. Cell 12(3):591-601 (2003).Mangeat, B., et al., Nature 424(6944):99-103 (2003).Zhang, H., et al., Nature 424(6944):94-98 (2003).Wedekind, J.E., et al., Trends Genet. 19(4):207-216 (2003).
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