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STRA8 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q7Z7C7
Clone Names 100408140
Peptide ID 100408140
Additional Information
Gene ID 346673
Other Names Stimulated by retinoic acid gene 8 protein homolog, STRA8 {ECO:0000312|EMBL:AAP471631}
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name STRA8 {ECO:0000312|EMBL:AAP47163.1}
Function Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germ cells, required for premeiotic DNA replication and subsequent events in meiotic prophase. During spermatogenesis, next to its role in meiotic initiation, promotes (but is not required for) spermatogonial differentiation. Can associate with DNA (possibly in an indirect manner), and in vitro can activate DNA transcription (By similarity).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:P70278}. Nucleus {ECO:0000250|UniProtKB:P70278}. Note=Shuttles between nucleus and cytoplasm. Nuclear export is XPO1-dependent {ECO:0000250|UniProtKB:P70278}
Tissue Location Expressed specifically in testis and fetal ovaries.
Research Areas
Citations (0)

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Background

This gene encodes a retinoic acid-responsive protein. Ahomologous protein in mouse has been shown to be involved in theregulation of meiotic initiation in both spermatogenesis andoogenesis, though feature differences between the mouse and humanproteins suggest that these homologs are not entirely functionallyequivalent. It is thought that this gene may play a role inspermatogenesis in humans.

References

Le Bouffant, R., et al. Hum. Reprod. 25(10):2579-2590(2010)Aston, K.I., et al. Hum. Reprod. 25(6):1383-1397(2010)Chen, B., et al. Asian J. Androl. 11(5):557-565(2009)Houmard, B., et al. Biol. Reprod. 81(2):438-443(2009)Stouffs, K., et al. Verh. K. Acad. Geneeskd. Belg. 71(3):115-139(2009)

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$ 80.00
Cat# BP11436b
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