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STRA8 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q7Z7C7 |
|---|---|
| Clone Names | 100408140 |
| Gene ID | 346673 |
|---|---|
| Other Names | Stimulated by retinoic acid gene 8 protein homolog, STRA8 {ECO:0000312|EMBL:AAP471631} |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | STRA8 (HGNC:30653) |
|---|---|
| Function | Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germ cells, acts downstream of ZGLP1 as a key effector of the meiotic program: required for premeiotic DNA replication and subsequent events in meiotic prophase. During spermatogenesis, next to its role in meiotic initiation, promotes (but is not required for) spermatogonial differentiation. In complex with MEIOSIN, directly activates the transcription of a subset of critical meiotic genes playing a central role in cell-cycle switching from mitosis to meiosis. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P70278}. Nucleus {ECO:0000250|UniProtKB:P70278}. Note=Shuttles between nucleus and cytoplasm. Nuclear export is XPO1-dependent {ECO:0000250|UniProtKB:P70278} |
| Tissue Location | Expressed specifically in testis and fetal ovaries. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a retinoic acid-responsive protein. Ahomologous protein in mouse has been shown to be involved in theregulation of meiotic initiation in both spermatogenesis andoogenesis, though feature differences between the mouse and humanproteins suggest that these homologs are not entirely functionallyequivalent. It is thought that this gene may play a role inspermatogenesis in humans.
References
Le Bouffant, R., et al. Hum. Reprod. 25(10):2579-2590(2010)Aston, K.I., et al. Hum. Reprod. 25(6):1383-1397(2010)Chen, B., et al. Asian J. Androl. 11(5):557-565(2009)Houmard, B., et al. Biol. Reprod. 81(2):438-443(2009)Stouffs, K., et al. Verh. K. Acad. Geneeskd. Belg. 71(3):115-139(2009)
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