CRFR1 Antibody (Q103) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P34998 |
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Clone Names | 5091953 |
Gene ID | 104909134;1394 |
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Other Names | Corticotropin-releasing factor receptor 1, CRF-R-1, CRF-R1, CRFR-1, Corticotropin-releasing hormone receptor 1, CRH-R-1, CRH-R1, CRHR1, CRFR, CRFR1, CRHR |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CRHR1 |
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Synonyms | CRFR, CRFR1, CRHR |
Function | G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. |
Cellular Location | Cell membrane; Multi-pass membrane protein. Endosome. Note=Agonist-binding promotes endocytosis |
Tissue Location | Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a G-protein coupled receptor that bindsneuropeptides of the corticotropin releasing hormone family thatare major regulators of the hypothalamic-pituitary-adrenal pathway.The encoded protein is essential for the activation of signaltransduction pathways that regulate diverse physiological processesincluding stress, reproduction, immune response and obesity.Alternative splicing results in multiple transcript variants.
References
Karteris, E., et al. Endocrinology 151(10):4959-4968(2010)Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)Hillhouse, E.W., et al. Endocr. Rev. 27(3):260-286(2006)
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