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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   CRFR1 Antibody (Q103) Blocking peptide   

CRFR1 Antibody (Q103) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P34998
Clone Names 5091953
Peptide ID 5091953
Additional Information
Gene ID 104909134;1394
Other Names Corticotropin-releasing factor receptor 1, CRF-R-1, CRF-R1, CRFR-1, Corticotropin-releasing hormone receptor 1, CRH-R-1, CRH-R1, CRHR1, CRFR, CRFR1, CRHR
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CRHR1
Synonyms CRFR, CRFR1, CRHR
Function G-protein coupled receptor for CRH (corticotropin- releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.
Cellular Location Cell membrane; Multi-pass membrane protein. Endosome. Note=Agonist-binding promotes endocytosis
Tissue Location Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe
Research Areas
Citations (0)

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This gene encodes a G-protein coupled receptor that bindsneuropeptides of the corticotropin releasing hormone family thatare major regulators of the hypothalamic-pituitary-adrenal pathway.The encoded protein is essential for the activation of signaltransduction pathways that regulate diverse physiological processesincluding stress, reproduction, immune response and obesity.Alternative splicing results in multiple transcript variants.


Karteris, E., et al. Endocrinology 151(10):4959-4968(2010)Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)Hillhouse, E.W., et al. Endocr. Rev. 27(3):260-286(2006)

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$ 80.00
Cat# BP11441a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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