JMJD2C Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9H3R0 |
---|---|
Clone Names | 6080533 |
Gene ID | 23081 |
---|---|
Other Names | Lysine-specific demethylase 4C, 11411-, Gene amplified in squamous cell carcinoma 1 protein, GASC-1 protein, JmjC domain-containing histone demethylation protein 3C, Jumonji domain-containing protein 2C, KDM4C, GASC1, JHDM3C, JMJD2C, KIAA0780 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | KDM4C |
---|---|
Synonyms | GASC1, JHDM3C, JMJD2C, KIAA0780 |
Function | Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537}. |
Tissue Location | Overexpressed in several esophageal squamous cell carcinomas (ESCs). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the Jumonji domain 2 (JMJD2)family and encodes a protein with one JmjC domain, one JmjN domain,two PHD-type zinc fingers, and two Tudor domains. This nuclearprotein functions as a trimethylation-specific demethylase,converting specific trimethylated histone residues to thedimethylated form. Chromosomal aberrations and increasedtranscriptional expression of this gene are associated withesophageal squamous cell carcinoma. Alternative splicing results inmultiple transcript variants.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Suikki, H.E., et al. Prostate 70(8):889-898(2010)Kantojarvi, K., et al. Psychiatr. Genet. 20(3):102-108(2010)Liu, G., et al. Oncogene 28(50):4491-4500(2009)Canova, C., et al. Cancer Res. 69(7):2956-2965(2009)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.