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JMJD2C Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9H3R0
Clone Names 6080533
Peptide ID 6080533
Additional Information
Gene ID 23081
Other Names Lysine-specific demethylase 4C, 11411-, Gene amplified in squamous cell carcinoma 1 protein, GASC-1 protein, JmjC domain-containing histone demethylation protein 3C, Jumonji domain-containing protein 2C, KDM4C, GASC1, JHDM3C, JMJD2C, KIAA0780
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KDM4C
Synonyms GASC1, JHDM3C, JMJD2C, KIAA0780
Function Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00537}
Tissue Location Overexpressed in several esophageal squamous cell carcinomas (ESCs).
Research Areas
Citations (0)

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This gene is a member of the Jumonji domain 2 (JMJD2)family and encodes a protein with one JmjC domain, one JmjN domain,two PHD-type zinc fingers, and two Tudor domains. This nuclearprotein functions as a trimethylation-specific demethylase,converting specific trimethylated histone residues to thedimethylated form. Chromosomal aberrations and increasedtranscriptional expression of this gene are associated withesophageal squamous cell carcinoma. Alternative splicing results inmultiple transcript variants.


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Suikki, H.E., et al. Prostate 70(8):889-898(2010)Kantojarvi, K., et al. Psychiatr. Genet. 20(3):102-108(2010)Liu, G., et al. Oncogene 28(50):4491-4500(2009)Canova, C., et al. Cancer Res. 69(7):2956-2965(2009)

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$ 80.00
Cat# BP11444b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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