|Other Names||Cysteine protease ATG4D, 3422-, AUT-like 4 cysteine endopeptidase, Autophagin-4, Autophagy-related cysteine endopeptidase 4, Autophagy-related protein 4 homolog D, Cysteine protease ATG4D, mitochondrial, ATG4D, APG4D, AUTL4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.|
|Cellular Location||Cysteine protease ATG4D: Cytoplasm|
|Tissue Location||Mainly expressed in skeletal muscle and, to a lower extent, in testis.|
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Provided below are standard protocols that you may find useful for product applications.
Autophagy is the process by which endogenous proteins anddamaged organelles are destroyed intracellularly. Autophagy ispostulated to be essential for cell homeostasis and cell remodelingduring differentiation, metamorphosis, non-apoptotic cell death,and aging. Reduced levels of autophagy have been described in somemalignant tumors, and a role for autophagy in controlling theunregulated cell growth linked to cancer has been proposed. Thisgene encodes a member of the autophagin protein family. The encodedprotein is also designated as a member of the C-54 family ofcysteine proteases.
Betin, V.M., et al. J. Cell. Sci. 122 (PT 14), 2554-2566 (2009) :Lamesch, P., et al. Genomics 89(3):307-315(2007)Marino, G., et al. J. Biol. Chem. 278(6):3671-3678(2003)
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