|Other Names||Collagen alpha-2(IV) chain, Canstatin, COL4A2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.|
|Cellular Location||Secreted, extracellular space, extracellular matrix, basement membrane|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes one of the six subunits of type IVcollagen, the major structural component of basement membranes. TheC-terminal portion of the protein, known as canstatin, is aninhibitor of angiogenesis and tumor growth. Like the other membersof the type IV collagen gene family, this gene is organized in ahead-to-head conformation with another type IV collagen gene sothat each gene pair shares a common promoter.
Bianchini, G., et al. J. Clin. Oncol. 28(28):4316-4323(2010)Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Romero, R., et al. Am. J. Obstet. Gynecol. 202 (5), 431 (2010) :Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
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