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HOPX Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9BPY8
Clone Names 80703021
Peptide ID 80703021
Additional Information
Gene ID 84525
Other Names Homeodomain-only protein, Lung cancer-associated Y protein, Not expressed in choriocarcinoma protein 1, Odd homeobox protein 1, HOPX, HOD, HOP, LAGY, NECC1, OB1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms HOD, HOP, LAGY, NECC1, OB1
Function Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor.
Cellular Location Nucleus {ECO:0000250|UniProtKB:Q8R1H0}. Cytoplasm {ECO:0000250|UniProtKB:Q8R1H0}
Tissue Location Widely expressed. Expressed in the heart, brain, placenta, lung, skeletal and smooth muscles, uterus, urinary bladder, kidney and spleen. Down-regulated in some types of cancer such as lung cancer, choriocarcinoma, head and neck squamous cell carcinoma and oral squamous cell carcinoma
Research Areas
Citations (0)

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The protein encoded by this gene is a homeodomain proteinthat lacks certain conserved residues required for DNA binding. Itwas reported that choriocarcinoma cell lines and tissues failed toexpress this gene, which suggested the possible involvement of thisgene in malignant conversion of placental trophoblasts. Studies inmice suggest that this protein may interact with serum responsefactor (SRF) and modulate SRF-dependent cardiac-specific geneexpression and cardiac development. Multiple alternatively splicedtranscript variants have been identified for this gene. [providedby RefSeq].


Yang, J.M., et al. Eur. J. Cell Biol. 89(7):537-546(2010)Ooki, A., et al. Oncogene 29(22):3263-3275(2010)Yamaguchi, S., et al. Int. J. Cancer 124(11):2577-2588(2009)Yamashita, K., et al. Mol. Cancer Res. 6(1):31-41(2008)De Toni, A., et al. Neural Dev 3, 13 (2008) :

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$ 80.00
Cat# BP11455b
Availability: In Stock
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