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HOPX Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BPY8 |
|---|---|
| Clone Names | 80703021 |
| Gene ID | 84525 |
|---|---|
| Other Names | Homeodomain-only protein, Lung cancer-associated Y protein, Not expressed in choriocarcinoma protein 1, Odd homeobox protein 1, HOPX, HOD, HOP, LAGY, NECC1, OB1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | HOPX |
|---|---|
| Synonyms | HOD, HOP, LAGY, NECC1, OB1 |
| Function | Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF- dependent cardiac-specific genes and cardiac development. Prevents SRF- dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding (PubMed:27708256). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q8R1H0}. Cytoplasm {ECO:0000250|UniProtKB:Q8R1H0} |
| Tissue Location | Widely expressed. Expressed in the heart, brain, placenta, lung, skeletal and smooth muscles, uterus, urinary bladder, kidney and spleen. Down-regulated in some types of cancer such as lung cancer, choriocarcinoma, head and neck squamous cell carcinoma and oral squamous cell carcinoma. |
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Background
The protein encoded by this gene is a homeodomain proteinthat lacks certain conserved residues required for DNA binding. Itwas reported that choriocarcinoma cell lines and tissues failed toexpress this gene, which suggested the possible involvement of thisgene in malignant conversion of placental trophoblasts. Studies inmice suggest that this protein may interact with serum responsefactor (SRF) and modulate SRF-dependent cardiac-specific geneexpression and cardiac development. Multiple alternatively splicedtranscript variants have been identified for this gene. [providedby RefSeq].
References
Yang, J.M., et al. Eur. J. Cell Biol. 89(7):537-546(2010)Ooki, A., et al. Oncogene 29(22):3263-3275(2010)Yamaguchi, S., et al. Int. J. Cancer 124(11):2577-2588(2009)Yamashita, K., et al. Mol. Cancer Res. 6(1):31-41(2008)De Toni, A., et al. Neural Dev 3, 13 (2008) :
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