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SCUBE2 Antibody (Center N266) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9NQ36
Other Accession NP_066025.2, NP_001164161.1
Clone Names 80924190
Peptide ID 80924190
Additional Information
Gene ID 57758
Other Names Signal peptide, CUB and EGF-like domain-containing protein 2, Protein CEGP1, SCUBE2, CEGP1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SCUBE2 (HGNC:30425)
Synonyms CEGP1
Function Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane (PubMed:22902404, PubMed:22677548). Acts by enhancing the proteolytic processing (shedding) of the lipid- modified N- and C- terminal of ShhNp at the cell surface (PubMed:24522195). Synergizes with DISP1 to increase SHH secretion (PubMed:22902404). Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis (PubMed:27834687).
Cellular Location Secreted. Cell surface. Note=Secreted and tethered at the cell surface (PubMed:19480626).
Tissue Location Expressed in a broad spectrum of adult tissues (PubMed:12270931).
Research Areas
Citations (0)

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References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)Hosgood, H.D. III, et al. Respir Med 103(12):1866-1870(2009)Tsai, M.T., et al. Biochem. J. 422(1):119-128(2009)Shen, M., et al. Environ. Mol. Mutagen. 50(4):285-290(2009)

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$ 80.00
Cat# BP11462c
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