|Other Names||Mitogen-activated protein kinase kinase kinase 15, Apoptosis signal-regulating kinase 3, MAPK/ERK kinase kinase 15, MEK kinase 15, MEKK 15, MAP3K15, ASK3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis.|
|Tissue Location||Isoform 2 and isoform 3 are widely expressed. Isoform 2 highest levels are observed in fetal brain, and isoform 3 highest levels in pancreas, peripheral blood leukocytes, fetal brain and spleen.|
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Provided below are standard protocols that you may find useful for product applications.
MEKK15 is a member of themitogen-activated protein kinase (MAPK) family. These familymembers function in a protein kinase signal transduction cascade,where an activated MAPK kinase kinase (MAP3K) phosphorylates andactivates a specific MAPK kinase (MAP2K), which then activates aspecific MAPK. This MAP3K protein plays an essential role inapoptotic cell death triggered by cellular stresses. [provided byRefSeq].
Kaji, T., et al. Biochem. Biophys. Res. Commun. 395(2):213-218(2010)
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