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STK36 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9NRP7
Clone Names 6030502
Additional Information
Gene ID 27148
Other Names Serine/threonine-protein kinase 36, Fused homolog, STK36 {ECO:0000312|EMBL:AAH261581}
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name STK36 {ECO:0000312|EMBL:AAH26158.1}
Function Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors (PubMed:10806483). Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization (PubMed:10806483). GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur (PubMed:10806483). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair apparatus of motile cilia.
Cellular Location Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, cilium axoneme. Note=Low levels also present in the nucleus.
Tissue Location Expressed at low levels in most fetal tissues, adult ovaries and at high levels in adult testis, where it is localized in germ cells (PubMed:10806483). Expressed in respiratory epithelial cells of the lung (PubMed:28543983).
Research Areas
Citations (0)
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Background

Serine/threonine protein kinase required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur.

References

Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Osterlund, T., et al. BMC Genomics 5 (1), 49 (2004) :Nakayama, M., et al. Genome Res. 12(11):1773-1784(2002)Murone, M., et al. Nat. Cell Biol. 2(5):310-312(2000)Gold, M.O., et al. J. Virol. 72(5):4448-4453(1998)

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$ 277.78
Cat# BP11543b
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