|Other Names||Phosphoinositide 3-kinase regulatory subunit 5, PI3-kinase regulatory subunit 5, PI3-kinase p101 subunit, Phosphatidylinositol 4, 5-bisphosphate 3-kinase regulatory subunit, PtdIns-3-kinase regulatory subunit, Protein FOAP-2, PtdIns-3-kinase p101, p101-PI3K, PIK3R5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity).|
|Cellular Location||Nucleus. Cytoplasm. Membrane; Peripheral membrane protein|
|Tissue Location||Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli.|
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Provided below are standard protocols that you may find useful for product applications.
Receptor-regulated class I phosphoinositide 3-kinases(PI3Ks) phosphorylate the membrane lipid phosphatidylinositol4,5-bisphosphate (PtdIns(4,5)P2) to PtdIns(3,4,5)P3, which in turnrecruits and activates cytosolic effectors involved inproliferation, survival, or chemotaxis. PIK3R5 is a PI3K regulatorysubunit (Brock et al., 2003 [PubMed 12507995]).
Rose, J. Phd, et al. Mol. Med. (2010) In press :Segat, L., et al. Vaccine 28(10):2201-2206(2010)Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)Johnson, C., et al. Oncogene 26(49):7049-7057(2007)Suire, S., et al. Curr. Biol. 15(6):566-570(2005)
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