|Other Names||POU domain, class 5, transcription factor 1, Octamer-binding protein 3, Oct-3, Octamer-binding protein 4, Oct-4, Octamer-binding transcription factor 3, OTF-3, POU5F1, OCT3, OCT4, OTF3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||OCT3, OCT4, OTF3|
|Function||Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.|
|Cellular Location||Cytoplasm. Nucleus. Note=Expressed in a diffuse and slightly punctuate pattern|
|Tissue Location||Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues.|
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This gene encodes a transcription factor containing a POUhomeodomain. This transcription factor plays a role in embryonicdevelopment, especially during early embryogenesis, and it isnecessary for embryonic stem cell pluripotency. A translocation ofthis gene with the Ewing's sarcoma gene, t(6;22)(p21;q12), has beenlinked to tumor formation. Alternative splicing, as well as usageof alternative translation initiation codons, results in multipleisoforms, one of which initiates at a non-AUG (CUG) start codon.Related pseudogenes have been identified on chromosomes 1, 3, 8,10, and 12.
Abu-Remaileh, M., et al. EMBO J. 29(19):3236-3248(2010)Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)Schultz, S.S., et al. Mol. Cell. Biol. 30(18):4521-4534(2010)Kim, S., et al. Br. J. Cancer 102(2):436-446(2010)Wang, X., et al. Stem Cells 27(6):1265-1275(2009)
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