OCT3/4 Antibody (C279) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q01860 |
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Clone Names | 71130128 |
Gene ID | 5460 |
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Other Names | POU domain, class 5, transcription factor 1, Octamer-binding protein 3, Oct-3, Octamer-binding protein 4, Oct-4, Octamer-binding transcription factor 3, OTF-3, POU5F1, OCT3, OCT4, OTF3 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | POU5F1 |
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Synonyms | OCT3, OCT4, OTF3 |
Function | Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. |
Cellular Location | Cytoplasm. Nucleus. Note=Expressed in a diffuse and slightly punctuate pattern. Colocalizes with MAPK8 and MAPK9 in the nucleus. {ECO:0000250|UniProtKB:P20263, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:19274063, ECO:0000269|PubMed:23024368} |
Tissue Location | Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a transcription factor containing a POUhomeodomain. This transcription factor plays a role in embryonicdevelopment, especially during early embryogenesis, and it isnecessary for embryonic stem cell pluripotency. A translocation ofthis gene with the Ewing's sarcoma gene, t(6;22)(p21;q12), has beenlinked to tumor formation. Alternative splicing, as well as usageof alternative translation initiation codons, results in multipleisoforms, one of which initiates at a non-AUG (CUG) start codon.Related pseudogenes have been identified on chromosomes 1, 3, 8,10, and 12.
References
Abu-Remaileh, M., et al. EMBO J. 29(19):3236-3248(2010)Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)Schultz, S.S., et al. Mol. Cell. Biol. 30(18):4521-4534(2010)Kim, S., et al. Br. J. Cancer 102(2):436-446(2010)Wang, X., et al. Stem Cells 27(6):1265-1275(2009)
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